Polydeoxyribonucleotide(PDRN)
PDRN (Polydeoxyribonucleotide) is a natural bioactive substance extracted and purified from specific salmon sperm DNA. Its core components are polymers of deoxyribonucleotides, typically ranging from 50 to 2000 base pairs in length. PDRN has garnered significant attention for its remarkable tissue repair and regeneration capabilities, particularly finding widespread application in medical aesthetics and wound healing.
The core mechanism of action for PDRN lies in its function as a "cellular messenger." When exogenous PDRN enters the human body, it is recognized and absorbed by cells. Primarily by activating the adenosine A2A receptor pathway, PDRN significantly promotes:
Tissue Repair and Regeneration: Accelerates fibroblast proliferation, migration, and the synthesis of collagen and elastin, thereby repairing damaged tissue.
Angiogenesis (New Blood Vessel Formation): Stimulates vascular endothelial cell growth, improving local microcirculation to deliver more oxygen and nutrients to damaged areas.
Anti-inflammatory Effects: Modulates the expression of inflammatory cytokines, reducing tissue inflammation and creating a more favorable environment for healing.
Cytoprotection (Cell Protection): Reduces oxidative stress damage, helping to preserve cell viability.
Leveraging these potent biological activities, PDRN is widely applied in:
Medical Aesthetics: Improving skin texture (fine lines, roughness, pores), enhancing firmness and elasticity, and boosting skin radiance and hydration (commonly used as a key ingredient in treatments like mesotherapy, microneedling, etc.).
Wound Healing: Accelerating the speed and quality of healing in chronic, hard-to-heal wounds (such as diabetic foot ulcers, pressure sores), burn wounds, and post-surgical trauma.
Regenerative Medicine: Assisting in the repair and regeneration of bone tissue, cartilage, and periodontal tissue in fields like orthopedics and dentistry.
Derived from natural sources, PDRN boasts excellent biocompatibility and safety. Its mechanism of action mimics crucial stages of the body's own natural healing process. Consequently, PDRN is recognized as a highly promising bioactive regenerative therapeutic agent, offering innovative solutions for promoting tissue repair, delaying aging signs, and improving skin health.
